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Technology

NC-T-001

NC-T-001: rTLH (Recombinant Thrombin-like Hemocoagulase)

Definition

Expressing a protein from the genes of Batroxobin in yeast with the gene recombinant technology, for overcoming the limitation of human origin thrombin

Development of Gene Recombinant Hemostatic Enzyme with high safety and production standardization

Mode of action

Cutting Fibrinogen α Chain at bleeding area into DesAA Fibrin

Inducing hemostatic by reducing blood coagulation time with helping the activated thrombin

“rTLH” is Safe and Stable
Hemocoagulase

Easy to supply (A protein expressed in Yeast)
Non animal origin, No risk of virus infection and practice of animal welfare
Possible the distribution and storage at the room temperature
Enable the product standardization through the simple production process
Available for injection because of not affecting coagulation factors and platelets
Not affected by anticoagulants such as heparin
Highly marketable, able to get approvals everywhere in the world

rTLH – CMCS PLATFORM

rTLH is in synergy with Carboxymethyl chitosan to high haemostasis effect by maximizing enzyme activity and strengthening blood coagulation.

Mode of Action

Carboxymethyl-chitosan

It induces the exudate absorption and coagulation of
     blood platelet & red blood cell.
The created blood clot protects the
     wound by the role of mechanical barrier.

rTLH(Recombinant Thrombin-Like Hemocoagulase)

It cuts Fibrinogen’s α chain. (Fibrinogen to DesAA Fibrin)
     DesAA Fibrin combines with platelets aggregation, forming the blood clot.
     That is, rTLH helps the activated thrombin at bleeding area, promoting hemostasis.